A culture of safety and quality is woven into the fabric of radiation oncology, with checks and balances at every level to ensure that the safest and most effective care is delivered to patients. Despite this culture that prioritizes safety and security, there remain attempts to limit access to these cost-effective treatments that often cure cancer by those concerned about radiologic incidents. The Nuclear Regulatory Commission has a strong track record and is uniquely situated to maintain safety and security for all domestic radioisotope users, including those used in radiation treatments. Further, it is the only agency within the federal government required to measure both the risks and the benefits of radioactive isotopes through the licensing process. Government mandates to abandon radioactive source-based technology in health care could result in less-efficient, less-effective cancer treatments and patients at risk.