Functional Radiation Medicine

Radiation therapy is most commonly recognized for its role in cancer treatment; however, its potential extends far beyond oncology. Emerging research and clinical applications demonstrate that radiation can play a significant role in enhancing patient quality of life by treating various non-oncologic conditions.

High‑dose radiation techniques, including stereotactic radiosurgery, are increasingly used to treat select neurologic conditions such as trigeminal neuralgia and other brain disorders. Additionally, low‑dose radiation therapy (LDRT) is also gaining renewed attention for its pain‑relieving effects for patients with disorders such as osteoarthritis and tendonitis, with growing interest in exploring innovative uses.

Low Dose Radiation Therapy Overview

• Growing Global Interest: There is an increasing international focus on the applications and potential of LDRT.
• Rich History: LDRT has been widely used in the management of musculoskeletal, inflammatory, and fibroproliferative diseases.
• Mechanisms of Action: LDRT exerts anti-inflammatory and anti-fibrotic effects, primarily through modulation of macrophage and cytokine activity. These biological effects may help reduce pain and improve mobility in affected patients.
• Need for Evidence: Rigorous, controlled clinical data are essential to validate the use of LDRT in these non-oncologic settings. Continued research and well-designed trials are critical to establishing best practices and ensuring patient safety.

Task Force

ASTRO’s Functional Radiation Medicine Task Force was established in late 2025 and is comprised of radiation oncologists and medical physicists from around the world who are currently using radiation for non-oncologic conditions. The Task Force is dedicated to advancing the safe, evidence-based use of radiation therapy for improved function and pain relief. By collaborating internationally, our members share expertise and pioneer new treatment protocols.

Mission

ASTRO’s Functional Radiation Medicine Task Force is dedicated to advancing the safe, evidence-based use of radiation therapy for nonmalignant conditions. The aim is to improve patient outcomes and quality of life by fostering high-quality research, generating clinical practice guidelines and consensus-based papers, and expanding the scope of practice and education for both trainees and practicing physicians.

To address the broad scope of functional radiation medicine, the Task Force is organized into three focused sub-groups:

• Musculoskeletal, Inflammatory and Skin Conditions: Investigating the role of LDRT in conditions such as arthritis, tendinopathies and dermatologic disorders.
• CNS / Functional Neurology: Exploring applications of radiation therapy in neurological and functional nervous system disorders.
• Cardiac Ablation: Focusing on the use of radiation therapy for cardiac arrhythmias and related conditions.