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ASTRO Guideline on Radiation Therapy for Rectal Cancer

Published: January/February 2021 (Webposted October 2020)

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This guideline provides guidance for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. It replaces ASTRO's 2016 guideline on rectal cancer. Recommendations address patient selection for radiation therapy, delivery of pelvic radiation treatments, options for non-operative management of locally advanced rectal cancer and guidance for follow-up care, as well as the integration of radiation with chemotherapy and surgery for stage II-III disease.

Developed in collaboration with:

  • American Society for Clinical Oncology
  • Society of Surgical Oncology

Endorsed by:

  • American College of Radiology 
  • Canadian Association of Radiation Oncology
  • European Society of Radiotherapy and Oncology
  • Royal Australian and New Zealand College of Radiologists
  • Society of Surgical Oncology


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