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ASTRO Guideline on External Beam Radiation Therapy for Primary Liver Cancers

Published: December 2021 (Web posted: October 2021)

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This guideline provides guidance on the definitive management of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC) with external beam radiation therapy (EBRT), including indications, outcomes, and techniques. It is intended to cover multiple settings for which EBRT may be used, including definitive, preoperative, salvage, consolidative, adjuvant, and as a bridge to transplant. Palliative management as it relates to EBRT for symptomatic primary liver cancers is also addressed

Developed in collaboration with:

  • American Society of Clinical Oncology
  • American Society of Transplant Surgeons
  • Society of Surgical Oncology

Endorsed by:

  • American Society of Transplant Surgeons
  • Canadian Association of Radiation Oncology
  • European Society for Radiotherapy and Oncology
  • Society of Surgical Oncology


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