ASTRO Guideline on Radiation Therapy for WHO Grade 4 Adult-Type Diffuse Glioma
Published: Web posted June 2025
This guideline addresses four key questions on the use of radiation therapy (RT) for management of World Health Organization (WHO) Grade 4 Adult-Type Diffuse Glioma. These questions include indications for radiation therapy (RT) and/or adjunctive therapies (e.g., systemic therapy, alternating electric field therapy), appropriate regimens for external beam RT after initial biopsy/resection including variables such as pretreatment characteristics, target volumes, technique, dose, reirradiation indications and techniques, and health disparities.
Developed in collaboration with:
- American Association of Neurological Surgeons/Congress of Neurological Surgeons
- American Association of Neuropathologists
- American Society of Clinical Oncology
- Society for Neuro-Oncology
Endorsed by:
- European Society for Radiotherapy and Oncology
- Royal Australian and New Zealand College of Radiologists
- Society for Neuro-Oncology
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