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ASTRO Guideline on Radiation Therapy for Glioblastoma

Published:  July 2016 (Web posted March 2016)

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The guideline addresses the following four areas regarding effective treatment of glioblastoma with radiation therapy: 1) when radiation is indicated following biopsy or resection of glioblastoma and how it is impacted by systemic therapy; 2) optimal dose-fractionation schemes for EBRT following biopsy or section and whether pretreatment characteristics like age or performance status affect appropriate fractionation; 3) ideal target volumes for curative-intent EBRT; and 4) the role of reirradiation in patients whose disease returns after initial treatment. 

Endorsed by:

  • American Society of Clinical Oncology

Key Points:

  • Ideal dose-fractionation and target volume design
  • Tumor-specific and patient-specific factors, including cytogenetics, performance status, and age, and the potential role of re-irradiation in recurrence


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