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ASTRO Guideline on Radiation Therapy for Treatment of Soft Tissue Sarcoma in Adults

Published: September/October 2021 (Web posted July 26, 2021)

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This guideline provides guidance on the use of radiation therapy to treat adult patients with soft tissue sarcoma (STS). Recommendations outline optimal radiation dosing, techniques and treatment planning for patients with localized, operable STS of the trunk (i.e., chest wall, abdominal wall) and extremities (i.e., arms, legs), with a focus on preserving long-term functionality through individualized care. The guideline additionally addresses the role for radiation therapy for retroperitoneal sarcoma. 

Developed in collaboration with:

  • American Society for Clinical Oncology
  • Musculoskeletal Tumor Society
  • Society of Surgical Oncology

Endorsed by:

  • Canadian Association of Radiation Oncology
  • European Society for Radiotherapy and Oncology
  • Musculoskeletal Tumor Society
  • Royal Australian and New Zealand College of Radiologists
  • Society of Surgical Oncology


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