Radiation therapy for glioblastoma

  • Publication
    Online – March 2016
    Print – July 2016

    The guideline addresses four areas regarding effective treatment of glioblastoma with radiation therapy. First, it provides recommendations on when radiation is indicated following biopsy or resection of glioblastoma and how it is impacted by systemic therapy. Second, it looks at the optimal dose-fractionation schemes for EBRT following biopsy or section and whether pretreatment characteristics like age or performance status affect appropriate fractionation. Third, it discusses ideal target volumes for curative-intent EBRT. Finally, the guideline considers the role of reirradiation in patients whose disease returns after initial treatment. 

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    Quick Reference

    • Ideal dose-fractionation and target volume design
    • Tumor-specific and patient-specific factors, including cytogenetics, performance status, and age, and the potential role of re-irradiation in recurrence

    Resources
    Imaging Brain Tumors: Practical Primer for the Radiation Oncologist
    Challenging Cases to CNS Current Approaches

    Author Society
    American Society for Radiation Oncology

    Previous version
    None

    Endorsements
    American Society of Clinical Oncology

  • Disclaimer

    ASTRO guidelines present scientific, health, and safety information and may reflect scientific or medical opinion. They are available to ASTRO members and the public for educational and informational purposes only. Commercial use of any content in this guideline without the prior written consent of ASTRO is strictly prohibited.