Day 3 - Saturday, March 2, 2024

Daily News Day 3 | 2024 Multidisciplinary Head and Neck Cancers Symposium

Read the Daily News for highlights from days 2 and 3 of the symposium.

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Assessment of hearing loss associated with use of concurrent radiation and cisplatin delivered weekly versus every three weeks in patients with locally advanced head and neck cancers

De-Intensification of Adjuvant Radiotherapy for HPV-Associated Squamous Cell Carcinomas of the Oropharynx:

Further Evidence that a Risk-Adapted Approach Yields Promise for Effective Treatment De-escalation

PD-L1 Expression May Not Correlate with Outcomes for Adjuvant Pembroluzimab

The combined positive score (CPS), which is defined as the number of PD-L1–staining cells (tumor cells, lymphocytes and macrophages) divided by the total number of viable tumor cells, multiplied by 100, is predictive of response to PD-1 blockade in the recurrent, metastatic setting. Robert Ferris, MD, and colleagues at the NRG, conducted a planned translational correlative study using biospecimens from NRG-HN003, which was a phase I study of definitive chemoradiotherapy and adjuvant pembroluzimab.

Intra-Treatment Metabolic Tumor Volume as a Biomarker for De-Escalation

Investigators from the University of Michigan presented data from a phase II trial evaluating the utility of mid-treatment FDG-PET/CT to guide the use of de-intensified chemoradiotherapy.

Favorable Toxicity and Maintained Oncologic Outcomes with Selective Contralateral Nodal Volume Irradiation:

Early Results of SAVER Phase I/II Trial for HPV-Related Oropharyngeal Cancer

HNCIG Consensus Recommendations for Radiographic Imaging-Detected Extranodal Extension in Head and Neck Cancer

Christina Henson, MD, and team reported consensus recommendations for radiographic imaging-detected extranodal extension in head and neck cancer, which is to harmonize and standardize the clinical practice and research.

Keynote II: The Evolving Role of Neoadjuvant Immunotherapy in Curative-Intent Head and Neck Cancer

For yesterday’s keynote, Ravindra Uppaluri, MD, PhD, Dana-Farber Cancer Center, Boston, spoke on the “Evolving Role of Neoadjuvant Immunotherapy in Curative-Intent Head and Neck Cancer.”




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