Phuoc Tran, MD, PhD
John Hopkins School of Medicine
2009 ASTRO Junior Faculty Research Training Award
Project title: Inducible SNA/1 Transgenic Mouse Model for Radiation Induced Pulmonary Fibrosis
Dr. Tran’s work explored radiation-induced pulmonary fibrosis (RIPF), a side effect of radiation therapy for lung cancer, and tested the hypothesis that myofibroblasts created by Epithelial-to-Mesenchymal Transition (EMT) of lung epithelial cells play a key role in producing this condition.
To do this, Dr. Tran successfully created a transgenic mouse model to study how myofibroblasts created through EMT are involved in RIPF. His hope is that the information and data gained from this project illuminates not only the process of EMT in RIPF but also contributes to the broader understanding of radiation-induced fibrosis throughout the body.