The successful delivery of radiation treatment involves
the careful efforts of everyone on the radiation oncology team.
As a part of its Target Safely
creates quality assurance
and safety white papers, which are an effort to investigate and develop modern risk-based and
process-focused quality assurance methods for radiotherapy treatment. These white
papers provide an opportunity to consolidate the abundant available guidance
and focus on preventing catastrophic failures.
In addition, ASTRO supported the creation of Quantitative Analyses
of Normal Tissues Effects in the Clinic (QUANTEC) reviews in association with the American
Association of Physicists in Medicine (AAPM). This series of papers offers focused
summaries of the dose/volume/outcome data for many of the organs potentially impacted by radiation treatment and gives physicians and treatment planners excellent resources to assist in
determining acceptable dose/volume constraints.
Showing 1 – 20 of 30 results found
- A Review of Safety, Quality Management and Practice Guidelines for High Dose-Rate Brachytherapy (2014)
white paper was commissioned by the American Society for Radiation Oncology
(ASTRO) Board of Directors to evaluate the status of safety and practice
guidance for high dose-rate (HDR) brachytherapy.
Read the journal article.
Read the full report.
- QA: Assuring Safety and Quality in Image-Guided Delivery of Radiation Therapy (2013)
Radiation therapy is an effective cancer treatment that is constantly being transformed by technological innovation. The white paper recommends foundational elements and specific activities to maximize the safety and effectiveness of IGRT.
Read the journal article.
Read the full report.
- QA: Enhancing the Role of Case-Oriented Peer Review to Improve Quality and Safety in Radiation Oncology (2013)
Peer review is one of the most effective means for assuring the quality of qualitative, and potentially controversial, patient-specific decisions in radiation oncology. This report summarizes many of the areas throughout radiation therapy that may benefit from the application of peer review.
Read the journal article
Read the full report
- QA: Quality and Safety Considerations in Intensity Modulated Radiation Therapy (IMRT)(2011)
This ASTRO white paper on IMRT critically evaluates guidance and literature on the safe delivery of this type of radiotherapy.
- QA: Quality and Safety Considerations in Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SRS/SBRT) (2011)
ASTRO’s white paper on SRS/SBRT delivery focuses on programmatic elements and human processes that can identify and correct potential sources of error that can result in catastrophic consequences.
- QUANTEC: Accurate Accumulation of Dose for Improved Understanding of Radiation Effects in Normal Tissue
To obtain the best possible therapeutic ratio, academia and
industry must develop new tools and models for linking true accumulated dose
and clinical outcome.
- QUANTEC: An Introduction to the Scientific Issues
This page traces developments in dose/volume/outcome modeling over the past twenty years and introduces the QUANTEC intiative.
- QUANTEC: Biomarkers and Surrogate Endpoints for Normal-Tissue Effects of Radiation Therapy: The Importance of Dose-Volume Effects
Radiobiology research into biomarkers for anticipating and
evaluating normal tissue toxicity is discussed in this QUANTEC paper. The
authors also look at future research priorities in this domain.
- QUANTEC: Imaging for Assessment of Radiation-Induced Normal Tissue Effects
Use of imaging to assess injury to normal tissue
due to radiation therapy would provide several benefits, but additional study is
needed to overcome the challenges of using imaging for this purpose and provide
- QUANTEC: Improving Normal Tissue Complication Probability Models: The Need to Adopt a “Data-Pooling” Culture
The authors advocate the use of repositories and pooling of data in order to enhance the capability to construct predictive models of normal tissue response.
- QUANTEC: Radiation Associated Brainstem Injury
Although the literature on brainstem injury from radiation is composed
primarily of small studies, this paper suggests fractionation limits to control
the risk of toxicity.
- QUANTEC: Radiation Dose-Volume Effects and the Penile Bulb
This QUANTEC paper considered the dose, volume and clinical outcome data for the penile bulb and discussed the association found in most studies between impotence and the dose and volume irradiated.
- QUANTEC: Radiation Dose-Volume Effects in Radiation-Induced Rectal Injury
Current data on rectal complications from
radiation therapy is reviewed in this QUANTEC paper. The literature indicates that
radiation dose and volume are consistently associated with high incidence of
- QUANTEC: Radiation Dose-Volume Effects in the Brain
An analysis of the literature on
radiotherapy-induced brain injury and the impact of dose and fraction size on
the incidence of adverse events.
- QUANTEC: Radiation Dose-Volume Effects in the Esophagus
This QUANTEC paper examines the clinical and
dosimetric parameters that have been associated with damage to the esophagus
after treatment with radiation.
- QUANTEC: Radiation Dose-Volume Effects in the Heart
The authors studied the existing data to
identify the main predictors for acute and late damage to the heart from
- QUANTEC: Radiation Dose-Volume Effects in the Larynx and Pharynx
This QUANTEC paper reviews the dose-volume outcome data for radiation dose and laryngeal edema, dysfunction and dysphagia.
- QUANTEC: Radiation Dose-Volume Effects in the Lung
Literature on dose, volume and outcome data for
lung suggests a relationship between pneumonitis and a variety of dosimetric
parameters, as well as strong volume and fractionation effects.
- QUANTEC: Radiation Dose-Volume Effects in the Spinal Cord
The QUANTEC paper on spinal cord injury after
radiation therapy evaluates the relationship between dose per fraction and the
risk of myelopathy.
- QUANTEC: Radiation Dose-Volume Effects in the Stomach and Small Bowel
In this QUANTEC paper, the authors evaluate the
current data available on the risk of radiation injury to the stomach and small
bowel and assess the challenges that exist in calculating the relationship
between dose and volume.